Predicting Cognitive Executive Functioning with Polygenic Risk Scores for Psychiatric Disorders.
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ABSTRACT:
SUBMITTER: Benca CE
PROVIDER: S-EPMC5225028 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Predicting Cognitive Executive Functioning with Polygenic Risk Scores for Psychiatric Disorders.
Benca Chelsie E CE Derringer Jaime L JL Corley Robin P RP Young Susan E SE Keller Matthew C MC Hewitt John K JK Friedman Naomi P NP
Behavior genetics 20161014 1
Executive functions (EFs) have been proposed as an endophenotype for psychopathology because EF deficits are associated with most psychiatric disorders. To examine this hypothesis, we derived polygenic risk scores for autism, attention-deficit/hyperactive disorder (ADHD), bipolar disorder, major depression (MDD), and schizophrenia, using genome-wide data from the Psychiatric Genomics Consortium as discovery samples. We then examined the relationships between these polygenic risk scores and three ...[more]
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