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Oncocytic Variant of Medullary Thyroid Carcinoma: A Rare Case of Sporadic Multifocal and Bilateral RET Wild-Type Neoplasm with Revision of the Literature.


ABSTRACT: Oncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland. It generally has a slight female predominance and appears as a single lesion. However in the Multiple Endocrine Neoplasia Syndrome 2, linked to the point mutation of RET oncogene, multifocal MTCs may also occur. Herein, we report the case of a 75 years old man with a rare form of sporadic multifocal and bilateral OV-MTC expressing wild-type RET gene. The histological and molecular features of this rare entity are presented and discussed with revision of the pertinent literature.

SUBMITTER: Vinciguerra GL 

PROVIDER: S-EPMC5226050 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Oncocytic Variant of Medullary Thyroid Carcinoma: A Rare Case of Sporadic Multifocal and Bilateral <i>RET</i> Wild-Type Neoplasm with Revision of the Literature.

Vinciguerra Gian Luca Rampioni GL   Noccioli Niccolò N   Cippitelli Claudia C   Minucci Angelo A   Capoluongo Ettore E   Bartolazzi Armando A  

Rare tumors 20161101 4


Oncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland. It generally has a slight female predominance and appears as a single lesion. However in the Multiple Endocrine Neoplasia Syndrome 2, linked to the point mutation of <i>RET</i> oncogene, multifocal MTCs may also occur. Herein, we report the case of a 75  ...[more]

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