Previous GWAS hits in relation to young-onset breast cancer.

ABSTRACT:

Purpose

Genome-wide association studies (GWAS) have identified dozens of single-nucleotide polymorphisms (SNPs) associated with breast cancer. Few studies focused on young-onset breast cancer, which exhibits etiologic and tumor-type differences from older-onset disease. Possible confounding by prenatal effects of the maternal genome has also not been considered.

Methods

Using a family-based design for breast cancer before age 50, we assessed the relationship between breast cancer and 77 GWAS-identified breast cancer risk SNPs. We estimated relative risks (RR) for inherited and maternally mediated genetic effects. We also used published RR estimates to calculate genetic risk scores and model joint effects.

Results

Seventeen of the candidate SNPs were nominally associat

SUBMITTER: Shi M 

PROVIDER: S-EPMC5226879 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature