Ontology highlight
ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC5227099 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Zhou Jin J Wu Zhong Z Wong Gabrielle G Pectasides Eirini E Nagaraja Ankur A Stachler Matthew M Zhang Haikuo H Chen Ting T Zhang Haisheng H Liu Jie Bin JB Xu Xinsen X Sicinska Ewa E Sanchez-Vega Francisco F Rustgi Anil K AK Diehl J Alan JA Wong Kwok-Kin KK Bass Adam J AJ
Nature communications 20170106
Oesophageal squamous cell carcinoma is a deadly disease where systemic therapy has relied upon empiric chemotherapy despite the presence of genomic alterations pointing to candidate therapeutic targets, including recurrent amplification of the gene encoding receptor tyrosine kinase epidermal growth factor receptor (EGFR). Here, we demonstrate that EGFR-targeting small-molecule inhibitors have efficacy in EGFR-amplified oesophageal squamous cell carcinoma (ESCC), but may become quickly ineffectiv ...[more]