Novel genetic loci underlying human intracranial volume identified through genome-wide association.
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ABSTRACT:
SUBMITTER: Adams HH
PROVIDER: S-EPMC5227112 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Novel genetic loci underlying human intracranial volume identified through genome-wide association.
Adams Hieab H H HH Hibar Derrek P DP Chouraki Vincent V Stein Jason L JL Nyquist Paul A PA Rentería Miguel E ME Trompet Stella S Arias-Vasquez Alejandro A Seshadri Sudha S Desrivières Sylvane S Beecham Ashley H AH Jahanshad Neda N Wittfeld Katharina K Van der Lee Sven J SJ Abramovic Lucija L Alhusaini Saud S Amin Najaf N Andersson Micael M Arfanakis Konstantinos K Aribisala Benjamin S BS Armstrong Nicola J NJ Athanasiu Lavinia L Axelsson Tomas T Beiser Alexa A Bernard Manon M Bis Joshua C JC Blanken Laura M E LM Blanton Susan H SH Bohlken Marc M MM Boks Marco P MP Bralten Janita J Brickman Adam M AM Carmichael Owen O Chakravarty M Mallar MM Chauhan Ganesh G Chen Qiang Q Ching Christopher R K CR Cuellar-Partida Gabriel G Braber Anouk Den AD Doan Nhat Trung NT Ehrlich Stefan S Filippi Irina I Ge Tian T Giddaluru Sudheer S Goldman Aaron L AL Gottesman Rebecca F RF Greven Corina U CU Grimm Oliver O Griswold Michael E ME Guadalupe Tulio T Hass Johanna J Haukvik Unn K UK Hilal Saima S Hofer Edith E Hoehn David D Holmes Avram J AJ Hoogman Martine M Janowitz Deborah D Jia Tianye T Kasperaviciute Dalia D Kim Sungeun S Klein Marieke M Kraemer Bernd B Lee Phil H PH Liao Jiemin J Liewald David C M DC Lopez Lorna M LM Luciano Michelle M Macare Christine C Marquand Andre A Matarin Mar M Mather Karen A KA Mattheisen Manuel M Mazoyer Bernard B McKay David R DR McWhirter Rebekah R Milaneschi Yuri Y Mirza-Schreiber Nazanin N Muetzel Ryan L RL Maniega Susana Muñoz SM Nho Kwangsik K Nugent Allison C AC Loohuis Loes M Olde LM Oosterlaan Jaap J Papmeyer Martina M Pappa Irene I Pirpamer Lukas L Pudas Sara S Pütz Benno B Rajan Kumar B KB Ramasamy Adaikalavan A Richards Jennifer S JS Risacher Shannon L SL Roiz-Santiañez Roberto R Rommelse Nanda N Rose Emma J EJ Royle Natalie A NA Rundek Tatjana T Sämann Philipp G PG Satizabal Claudia L CL Schmaal Lianne L Schork Andrew J AJ Shen Li L Shin Jean J Shumskaya Elena E Smith Albert V AV Sprooten Emma E Strike Lachlan T LT Teumer Alexander A Thomson Russell R Tordesillas-Gutierrez Diana D Toro Roberto R Trabzuni Daniah D Vaidya Dhananjay D Van der Grond Jeroen J Van der Meer Dennis D Van Donkelaar Marjolein M J MM Van Eijk Kristel R KR Van Erp Theo G M TG Van Rooij Daan D Walton Esther E Westlye Lars T LT Whelan Christopher D CD Windham Beverly G BG Winkler Anderson M AM Woldehawariat Girma G Wolf Christiane C Wolfers Thomas T Xu Bing B Yanek Lisa R LR Yang Jingyun J Zijdenbos Alex A Zwiers Marcel P MP Agartz Ingrid I Aggarwal Neelum T NT Almasy Laura L Ames David D Amouyel Philippe P Andreassen Ole A OA Arepalli Sampath S Assareh Amelia A AA Barral Sandra S Bastin Mark E ME Becker Diane M DM Becker James T JT Bennett David A DA Blangero John J van Bokhoven Hans H Boomsma Dorret I DI Brodaty Henry H Brouwer Rachel M RM Brunner Han G HG Buckner Randy L RL Buitelaar Jan K JK Bulayeva Kazima B KB Cahn Wiepke W Calhoun Vince D VD Cannon Dara M DM Cavalleri Gianpiero L GL Chen Christopher C Cheng Ching-Yu CY Cichon Sven S Cookson Mark R MR Corvin Aiden A Crespo-Facorro Benedicto B Curran Joanne E JE Czisch Michael M Dale Anders M AM Davies Gareth E GE De Geus Eco J C EJ De Jager Philip L PL de Zubicaray Greig I GI Delanty Norman N Depondt Chantal C DeStefano Anita L AL Dillman Allissa A Djurovic Srdjan S Donohoe Gary G Drevets Wayne C WC Duggirala Ravi R Dyer Thomas D TD Erk Susanne S Espeseth Thomas T Evans Denis A DA Fedko Iryna O IO Fernández Guillén G Ferrucci Luigi L Fisher Simon E SE Fleischman Debra A DA Ford Ian I Foroud Tatiana M TM Fox Peter T PT Francks Clyde C Fukunaga Masaki M Gibbs J Raphael JR Glahn David C DC Gollub Randy L RL Göring Harald H H HH Grabe Hans J HJ Green Robert C RC Gruber Oliver O Gudnason Vilmundur V Guelfi Sebastian S Hansell Narelle K NK Hardy John J Hartman Catharina A CA Hashimoto Ryota R Hegenscheid Katrin K Heinz Andreas A Le Hellard Stephanie S Hernandez Dena G DG Heslenfeld Dirk J DJ Ho Beng-Choon BC Hoekstra Pieter J PJ Hoffmann Wolfgang W Hofman Albert A Holsboer Florian F Homuth Georg G Hosten Norbert N Hottenga Jouke-Jan JJ Hulshoff Pol Hilleke E HE Ikeda Masashi M Ikram M Kamran MK Jack Clifford R CR Jenkinson Mark M Johnson Robert R Jönsson Erik G EG Jukema J Wouter JW Kahn René S RS Kanai Ryota R Kloszewska Iwona I Knopman David S DS Kochunov Peter P Kwok John B JB Lawrie Stephen M SM Lemaître Hervé H Liu Xinmin X Longo Dan L DL Longstreth W T WT Lopez Oscar L OL Lovestone Simon S Martinez Oliver O Martinot Jean-Luc JL Mattay Venkata S VS McDonald Colm C McIntosh Andrew M AM McMahon Katie L KL McMahon Francis J FJ Mecocci Patrizia P Melle Ingrid I Meyer-Lindenberg Andreas A Mohnke Sebastian S Montgomery Grant W GW Morris Derek W DW Mosley Thomas H TH Mühleisen Thomas W TW Müller-Myhsok Bertram B Nalls Michael A MA Nauck Matthias M Nichols Thomas E TE Niessen Wiro J WJ Nöthen Markus M MM Nyberg Lars L Ohi Kazutaka K Olvera Rene L RL Ophoff Roel A RA Pandolfo Massimo M Paus Tomas T Pausova Zdenka Z Penninx Brenda W J H BW Pike G Bruce GB Potkin Steven G SG Psaty Bruce M BM Reppermund Simone S Rietschel Marcella M Roffman Joshua L JL Romanczuk-Seiferth Nina N Rotter Jerome I JI Ryten Mina M Sacco Ralph L RL Sachdev Perminder S PS Saykin Andrew J AJ Schmidt Reinhold R Schofield Peter R PR Sigurdsson Sigurdur S Simmons Andy A Singleton Andrew A Sisodiya Sanjay M SM Smith Colin C Smoller Jordan W JW Soininen Hilkka H Srikanth Velandai V Steen Vidar M VM Stott David J DJ Sussmann Jessika E JE Thalamuthu Anbupalam A Tiemeier Henning H Toga Arthur W AW Traynor Bryan J BJ Troncoso Juan J Turner Jessica A JA Tzourio Christophe C Uitterlinden Andre G AG Hernández Maria C Valdés MC Van der Brug Marcel M Van der Lugt Aad A Van der Wee Nic J A NJ Van Duijn Cornelia M CM Van Haren Neeltje E M NE Van T Ent Dennis D Van Tol Marie-Jose MJ Vardarajan Badri N BN Veltman Dick J DJ Vernooij Meike W MW Völzke Henry H Walter Henrik H Wardlaw Joanna M JM Wassink Thomas H TH Weale Michael E ME Weinberger Daniel R DR Weiner Michael W MW Wen Wei W Westman Eric E White Tonya T Wong Tien Y TY Wright Clinton B CB Zielke H Ronald HR Zonderman Alan B AB Deary Ian J IJ DeCarli Charles C Schmidt Helena H Martin Nicholas G NG De Craen Anton J M AJ Wright Margaret J MJ Launer Lenore J LJ Schumann Gunter G Fornage Myriam M Franke Barbara B Debette Stéphanie S Medland Sarah E SE Ikram M Arfan MA Thompson Paul M PM
Nature neuroscience 20161003 12
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjustin ...[more]