Unknown

Dataset Information

0

The -938C>A Polymorphism in MYD88 Is Associated with Susceptibility to Tuberculosis: A Pilot Study.

ABSTRACT: Introduction. Tuberculosis (TB) is a major disease worldwide, caused by Mycobacterium tuberculosis (MTB) infection. The Toll-Like Receptor (TLR) pathway plays a crucial role in the recognition of MTB. Aim. The present study aimed to investigate the involvement of myeloid differentiation primary response protein 88 (MYD88) gene polymorphisms in TB. Materials and Methods. A total of 103 TB cases and 92 control subjects were genotyped for the MYD88 -938C>A (rs4988453) and 1944C>G (rs4988457) polymorphisms. Results. The MYD88 -938CA and -938AA genotypes were associated with an increased risk for tuberculosis with odds ratio (OR) of 5.71 (95% confidence intervals [CIs] 2.89-11.28, p = 0.01). Conclusions. The MYD88 -938C>A genetic polymorphism is associated with increased susceptibility to TB and may serve as a marker to screen individuals who are at risk.

SUBMITTER: Aggelou K 

PROVIDER: S-EPMC5227150 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The -938C>A Polymorphism in <i>MYD88</i> Is Associated with Susceptibility to Tuberculosis: A Pilot Study.

Aggelou Kalliopi K   Siapati Elena Konstantina EK   Gerogianni Irini I   Daniil Zoe Z   Gourgoulianis Konstantinos K   Ntanos Ioannis I   Simantirakis Emmanouel E   Zintzaras Elias E   Mollaki Vassiliki V   Vassilopoulos George G  

Disease markers 20161229

<i>Introduction</i>. Tuberculosis (TB) is a major disease worldwide, caused by Mycobacterium tuberculosis (MTB) infection. The Toll-Like Receptor (TLR) pathway plays a crucial role in the recognition of MTB. <i>Aim</i>. The present study aimed to investigate the involvement of myeloid differentiation primary response protein 88 (<i>MYD88</i>) gene polymorphisms in TB. <i>Materials and Methods</i>. A total of 103 TB cases and 92 control subjects were genotyped for the <i>MYD88 -</i>938C>A (rs4988  ...[more]

Similar Datasets

Unknown A polymorphism in human CD1A is associated with susceptibility to tuberculosis.
| S-EPMC3998877 | biostudies-literature
Unknown Functional Polymorphism in the <i>NFE2L2</i> Gene Associated With Tuberculosis Susceptibility.
| S-EPMC8181729 | biostudies-literature
Unknown TLR2 Arg753Gln Gene Polymorphism Associated with Tuberculosis Susceptibility: An Updated Meta-Analysis.
| S-EPMC6348792 | biostudies-literature
Unknown C-Reactive Protein +1444C/T Polymorphism Is Associated with the Susceptibility to Pulmonary Tuberculosis.
| S-EPMC7769630 | biostudies-literature
Unknown Melanocortin-3-receptor promoter polymorphism associated with tuberculosis susceptibility does not influence protein expression.
| S-EPMC3605127 | biostudies-literature
Unknown A polymorphism in human MR1 is associated with mRNA expression and susceptibility to tuberculosis.
| S-EPMC5269436 | biostudies-literature
Unknown Lymphotoxin-Alpha Gene Polymorphism +252A/G (rs909253, A/G) Is Associated with Susceptibility to Chronic Periodontitis: A Pilot Study.
| S-EPMC3463161 | biostudies-literature
Unknown Influence of Genetic Polymorphism Towards Pulmonary Tuberculosis Susceptibility.
| S-EPMC6106802 | biostudies-literature
Unknown Genetic polymorphism in association with susceptibility to tuberculosis: a study in a Pakistani population.
| S-EPMC6863315 | biostudies-literature
Unknown Polymorphism in the EREG gene confers susceptibility to tuberculosis.
| S-EPMC6329172 | biostudies-literature