Ontology highlight
ABSTRACT:
SUBMITTER: Krautkramer KA
PROVIDER: S-EPMC5227652 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Krautkramer Kimberly A KA Kreznar Julia H JH Romano Kymberleigh A KA Vivas Eugenio I EI Barrett-Wilt Gregory A GA Rabaglia Mary E ME Keller Mark P MP Attie Alan D AD Rey Federico E FE Denu John M JM
Molecular cell 20161123 5
Histone-modifying enzymes regulate transcription and are sensitive to availability of endogenous small-molecule metabolites, allowing chromatin to respond to changes in environment. The gut microbiota produces a myriad of metabolites that affect host physiology and susceptibility to disease; however, the underlying molecular events remain largely unknown. Here we demonstrate that microbial colonization regulates global histone acetylation and methylation in multiple host tissues in a diet-depend ...[more]