Ontology highlight
ABSTRACT:
SUBMITTER: Churcher TS
PROVIDER: S-EPMC5230737 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Churcher Thomas S TS Sinden Robert E RE Edwards Nick J NJ Poulton Ian D ID Rampling Thomas W TW Brock Patrick M PM Griffin Jamie T JT Upton Leanna M LM Zakutansky Sara E SE Sala Katarzyna A KA Angrisano Fiona F Hill Adrian V S AV Blagborough Andrew M AM
PLoS pathogens 20170112 1
Over a century since Ronald Ross discovered that malaria is caused by the bite of an infectious mosquito it is still unclear how the number of parasites injected influences disease transmission. Currently it is assumed that all mosquitoes with salivary gland sporozoites are equally infectious irrespective of the number of parasites they harbour, though this has never been rigorously tested. Here we analyse >1000 experimental infections of humans and mice and demonstrate a dose-dependency for pro ...[more]