Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease.
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ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC5233612 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
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Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease.
Zhang Xuelin X Wang Yang Y Liu Pingsheng P
Protein & cell 20161018 1
Non-alcoholic fatty liver disease (NAFLD) is an epidemic metabolic condition driven by an underlying lipid homeostasis disorder. The lipid droplet (LD), the main organelle involved in neutral lipid storage and hydrolysis, is a potential target for NAFLD therapeutic treatment. In this review, we summarize recent progress elucidating the connections between LD-associated proteins and NAFLD found by genome-wide association studies (GWAS), genomic and proteomic studies. Finally, we discuss a possibl ...[more]
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