Ontology highlight
ABSTRACT:
SUBMITTER: Ong EZ
PROVIDER: S-EPMC5234037 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Ong Eugenia Z EZ Zhang Summer L SL Tan Hwee Cheng HC Gan Esther S ES Chan Kuan Rong KR Ooi Eng Eong EE
Scientific reports 20170113
Secondary infection with a heterologous dengue virus (DENV) serotype increases the risk of severe dengue, through a process termed antibody-dependent enhancement (ADE). During ADE, DENV is opsonized with non- or sub-neutralizing antibody levels that augment entry into monocytes and dendritic cells through Fc-gamma receptors (FcγRs). We previously reported that co-ligation of leukocyte immunoglobulin-like receptor-B1 (LILRB1) by antibody-opsonized DENV led to recruitment of SH2 domain-containing ...[more]