Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC5234852 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Li Zejuan Z Weng Hengyou H Su Rui R Weng Xiaocheng X Zuo Zhixiang Z Li Chenying C Huang Huilin H Nachtergaele Sigrid S Dong Lei L Hu Chao C Qin Xi X Tang Lichun L Wang Yungui Y Hong Gia-Ming GM Huang Hao H Wang Xiao X Chen Ping P Gurbuxani Sandeep S Arnovitz Stephen S Li Yuanyuan Y Li Shenglai S Strong Jennifer J Neilly Mary Beth MB Larson Richard A RA Jiang Xi X Zhang Pumin P Jin Jie J He Chuan C Chen Jianjun J
Cancer cell 20161222 1
N<sup>6</sup>-Methyladenosine (m<sup>6</sup>A) represents the most prevalent internal modification in mammalian mRNAs. Despite its functional importance in various fundamental bioprocesses, the studies of m<sup>6</sup>A in cancer have been limited. Here we show that FTO, as an m<sup>6</sup>A demethylase, plays a critical oncogenic role in acute myeloid leukemia (AML). FTO is highly expressed in AMLs with t(11q23)/MLL rearrangements, t(15;17)/PML-RARA, FLT3-ITD, and/or NPM1 mutations. FTO enhance ...[more]