Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC7341103 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Li Yize Y Guo Xinying X Sun Linlin L Xiao Jifang J Su Songxue S Du Shibin S Li Zhen Z Wu Shaogen S Liu Weili W Mo Kai K Xia Shangzhou S Chang Yun-Juan YJ Denis Daniel D Tao Yuan-Xiang YX
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20200527 13
Nerve injury-induced change in gene expression in primary sensory neurons of dorsal root ganglion (DRG) is critical for neuropathic pain genesis. N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) modification of RNA represents an additional layer of gene regulation. Here, it is reported that peripheral nerve injury increases the expression of the m<sup>6</sup>A demethylase fat-mass and obesity-associated proteins (FTO) in the injured DRG via the activation of Runx1, a transcription factor that bind ...[more]