High-speed and high-sensitivity parallel spectral-domain optical coherence tomography using a supercontinuum light source.

ABSTRACT: The three most important metrics in optical coherence tomography (OCT) are resolution, speed, and sensitivity. Because there is a complex interplay between these metrics, no previous work has obtained the best performance in all three metrics simultaneously. We demonstrate that a high-power supercontinuum source, in combination with parallel spectral-domain OCT, achieves an unparalleled combination of resolution, speed, and sensitivity. This system captures cross-sectional images spanning 4??mm×0.5??mm at 1,024,000 lines/s with 2×14???m resolution (axial×transverse) at a sensitivity of 113 dB. Imaging using the proposed system is demonstrated on highly differentiated human bronchial epithelial cells to capture and spatially localize ciliary dynamics.

SUBMITTER: Barrick J 

PROVIDER: S-EPMC5235345 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature