Ontology highlight
ABSTRACT:
SUBMITTER: Abbink P
PROVIDER: S-EPMC5237380 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Abbink Peter P Larocca Rafael A RA De La Barrera Rafael A RA Bricault Christine A CA Moseley Edward T ET Boyd Michael M Kirilova Marinela M Li Zhenfeng Z Ng'ang'a David D Nanayakkara Ovini O Nityanandam Ramya R Mercado Noe B NB Borducchi Erica N EN Agarwal Arshi A Brinkman Amanda L AL Cabral Crystal C Chandrashekar Abishek A Giglio Patricia B PB Jetton David D Jimenez Jessica J Lee Benjamin C BC Mojta Shanell S Molloy Katherine K Shetty Mayuri M Neubauer George H GH Stephenson Kathryn E KE Peron Jean Pierre S JP Zanotto Paolo M de A PM Misamore Johnathan J Finneyfrock Brad B Lewis Mark G MG Alter Galit G Modjarrad Kayvon K Jarman Richard G RG Eckels Kenneth H KH Michael Nelson L NL Thomas Stephen J SJ Barouch Dan H DH
Science (New York, N.Y.) 20160804 6304
Zika virus (ZIKV) is responsible for a major ongoing epidemic in the Americas and has been causally associated with fetal microcephaly. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Here we demonstrate that three different vaccine platforms protect against ZIKV challenge in rhesus monkeys. A purified inactivated virus vaccine induced ZIKV-specific neutralizing antibodies and completely protected monkeys against ZIKV strains from both Brazil a ...[more]