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Coated protein nanoclusters from influenza H7N9 HA are highly immunogenic and induce robust protective immunity.


ABSTRACT: Recurring influenza viruses pose an annual threat to public health. A time-saving, cost-effective and egg-independent influenza vaccine approach is important particularly when responding to an emerging pandemic. We fabricated coated, two-layer protein nanoclusters from recombinant trimeric hemagglutinin from an avian-origin H7N9 influenza A virus as an approach for vaccine development in response to an emerging pandemic. Assessment of the virus-specific immune responses and protective efficacy in mice immunized with the nanoclusters demonstrated that the vaccine candidates were highly immunogenic, able to induce protective immunity and long-lasting humoral antibody responses to this virus without the use of adjuvants. Because the advantages of the highly immunogenic coated nanoclusters also include rapid productions in an egg-independent system, this approach has great potential for influenza vaccine production not only in response to an emerging pandemic, but also as a replacement for conventional seasonal influenza vaccines.

SUBMITTER: Wang L 

PROVIDER: S-EPMC5237404 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Coated protein nanoclusters from influenza H7N9 HA are highly immunogenic and induce robust protective immunity.

Wang Li L   Chang Timothy Z TZ   He Yuan Y   Kim Jong R JR   Wang Shelly S   Mohan Teena T   Berman Zachary Z   Tompkins S Mark SM   Tripp Ralph A RA   Compans Richard W RW   Champion Julie A JA   Wang Bao-Zhong BZ  

Nanomedicine : nanotechnology, biology, and medicine 20160910 1


Recurring influenza viruses pose an annual threat to public health. A time-saving, cost-effective and egg-independent influenza vaccine approach is important particularly when responding to an emerging pandemic. We fabricated coated, two-layer protein nanoclusters from recombinant trimeric hemagglutinin from an avian-origin H7N9 influenza A virus as an approach for vaccine development in response to an emerging pandemic. Assessment of the virus-specific immune responses and protective efficacy i  ...[more]

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