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A highly immunogenic vaccine against A/H7N9 influenza virus.

ABSTRACT: Since the first case of human infection in March 2013, continued reports of H7N9 cases highlight a potential pandemic threat. Highly immunogenic vaccines to this virus are urgently needed to protect vulnerable populations who lack protective immunity. In this study, an egg- and adjuvant-independent adenoviral vector-based, hemagglutinin H7 subtype influenza vaccine (HAd-H7HA) demonstrated enhanced cell-mediated immunity as well as serum antibody responses in a mouse model. Most importantly, this vaccine provided complete protection against homologous A/H7N9 viral challenge suggesting its potential utility as a pandemic vaccine.

SUBMITTER: Cao W

PROVIDER: S-EPMC4735641 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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A highly immunogenic vaccine against A/H7N9 influenza virus.

Cao Weiping W Liepkalns Justine S JS Hassan Ahmed O AO Kamal Ram P RP Hofstetter Amelia R AR Amoah Samuel S Kim Jin Hyang JH Reber Adrian J AJ Stevens James J Katz Jacqueline M JM Gangappa Shivaprakash S York Ian A IA Mittal Suresh K SK Sambhara Suryaprakash S

Vaccine 20160104 6

Since the first case of human infection in March 2013, continued reports of H7N9 cases highlight a potential pandemic threat. Highly immunogenic vaccines to this virus are urgently needed to protect vulnerable populations who lack protective immunity. In this study, an egg- and adjuvant-independent adenoviral vector-based, hemagglutinin H7 subtype influenza vaccine (HAd-H7HA) demonstrated enhanced cell-mediated immunity as well as serum antibody responses in a mouse model. Most importantly, this ...[more]

PMID: 26765287

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Glycosylation generates an efficacious and immunogenic vaccine against H7N9 influenza virus.

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H7N9 Live Attenuated Influenza Vaccine Is Highly Immunogenic, Prevents Virus Replication, and Protects Against Severe Bronchopneumonia in Ferrets.

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