Ontology highlight
ABSTRACT:
SUBMITTER: Gomez-Diaz E
PROVIDER: S-EPMC5238449 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Gómez-Díaz Elena E Yerbanga Rakiswendé S RS Lefèvre Thierry T Cohuet Anna A Rowley M Jordan MJ Ouedraogo Jean Bosco JB Corces Victor G VG
Scientific reports 20170116
P. falciparum phenotypic plasticity is linked to the variant expression of clonal multigene families such as the var genes. We have examined changes in transcription and histone modifications that occur during sporogonic development of P. falciparum in the mosquito host. All var genes are silenced or transcribed at low levels in blood stages (gametocyte/ring) of the parasite in the human host. After infection of mosquitoes, a single var gene is selected for expression in the oocyst, and transcri ...[more]