Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension.
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ABSTRACT:
SUBMITTER: Petrilli WL
PROVIDER: S-EPMC5238464 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
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Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension.
Petrilli Whitney L WL Hoyt Scott B SB London Clare C McMasters Daniel D Verras Andreas A Struthers Mary M Cully Doris D Wisniewski Thomas T Ren Ning N Bopp Charlene C Sok Andrea A Chen Qing Q Li Ying Y Tung Elaine E Tang Wei W Salituro Gino G Knemeyer Ian I Karanam Bindhu B Clemas Joseph J Zhou Gaochao G Gibson Jack J Shipley Carrie Ann CA MacNeil Douglas J DJ Duffy Ruth R Tata James R JR Ujjainwalla Feroze F Ali Amjad A Xiong Yusheng Y
ACS medicinal chemistry letters 20161122 1
Herein we report the discovery and hit-to-lead optimization of a series of spirocyclic piperidine aldosterone synthase (CYP11B2) inhibitors. Compounds from this series display potent CYP11B2 inhibition, good selectivity versus related CYP enzymes, and lead-like physical and pharmacokinetic properties. ...[more]
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