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The synthesis of ?-aryl-?-aminophosphonates and ?-aryl-?-aminophosphine oxides by the microwave-assisted Pudovik reaction.

ABSTRACT: A family of ?-aryl-?-aminophosphonates and ?-aryl-?-aminophosphine oxides was synthesized by the microwave-assisted solvent-free addition of dialkyl phosphites and diphenylphosphine oxide, respectively, to imines formed from benzaldehyde derivatives and primary amines. After optimization, the reactivity was mapped, and the fine mechanism was evaluated by DFT calculations. Two ?-aminophosphonates were subjected to an X-ray study revealing a racemic dimer formation made through a N-H···O=P intermolecular hydrogen bridges pair.

SUBMITTER: Balint E

PROVIDER: S-EPMC5238548 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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The synthesis of α-aryl-α-aminophosphonates and α-aryl-α-aminophosphine oxides by the microwave-assisted Pudovik reaction.

Bálint Erika E Tajti Ádám Á Ádám Anna A Csontos István I Karaghiosoff Konstantin K Czugler Mátyás M Ábrányi-Balogh Péter P Keglevich György G

Beilstein journal of organic chemistry 20170112

A family of α-aryl-α-aminophosphonates and α-aryl-α-aminophosphine oxides was synthesized by the microwave-assisted solvent-free addition of dialkyl phosphites and diphenylphosphine oxide, respectively, to imines formed from benzaldehyde derivatives and primary amines. After optimization, the reactivity was mapped, and the fine mechanism was evaluated by DFT calculations. Two α-aminophosphonates were subjected to an X-ray study revealing a racemic dimer formation made through a N-H···O=P intermo ...[more]

PMID: 28179951

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