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One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool.

ABSTRACT: A methodology is reported for the preparation of 2-aryl-benzimidazole-3-oxide derivatives. By means of a one-pot two-step protocol, a library of 42 new compounds has been prepared. Reactions were performed in a total time of 40 min using microwave heating as a tool. A streamlined work-up process was also developed, allowing for facile isolation of the products. The methodology offers a more sustainable approach than previous routes, with only water and ethanol being used as solvents, and the products being isolated by means of a simple filtration without the need for any further purification.

SUBMITTER: Politano F

PROVIDER: S-EPMC6832536 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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One-Pot Two-Step Synthesis of 2-Aryl benzimidazole <i>N</i>-oxides Using Microwave Heating as a Tool.

Politano Fabrizio F Gran-Magano Ana K AK Leadbeater Nicholas E NE

Molecules (Basel, Switzerland) 20191009 20

A methodology is reported for the preparation of 2-aryl-benzimidazole-3-oxide derivatives. By means of a one-pot two-step protocol, a library of 42 new compounds has been prepared. Reactions were performed in a total time of 40 min using microwave heating as a tool. A streamlined work-up process was also developed, allowing for facile isolation of the products. The methodology offers a more sustainable approach than previous routes, with only water and ethanol being used as solvents, and the pro ...[more]

PMID: 31600970

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