Ontology highlight
ABSTRACT:
SUBMITTER: Brenna D
PROVIDER: S-EPMC5238568 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Brenna Davide D Massolo Elisabetta E Puglisi Alessandra A Rossi Sergio S Celentano Giuseppe G Benaglia Maurizio M Capriati Vito V
Beilstein journal of organic chemistry 20161205
Different deep eutectic solvent (DES) mixtures were studied as reaction media for the continuous synthesis of enantiomerically enriched products by testing different experimental set-ups. L-Proline-catalysed cross-aldol reactions were efficiently performed in continuo, with high yield (99%), <i>anti-</i>stereoselectivity, and enantioselectivity (up to 97% ee). Moreover, using two different DES mixtures, the diastereoselectivity of the process could be tuned, thereby leading to the formation, und ...[more]