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Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins.


ABSTRACT: The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under dry-grinding conditions was also performed. The results showed that the cyclization reaction was influenced by the amount of the PEG grinding agents. In general, cleaner reaction profiles were observed in the presence of PEGs, compared to dry-grinding procedures.

SUBMITTER: Mascitti A 

PROVIDER: S-EPMC5238572 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins.

Mascitti Andrea A   Lupacchini Massimiliano M   Guerra Ruben R   Taydakov Ilya I   Tonucci Lucia L   d'Alessandro Nicola N   Lamaty Frederic F   Martinez Jean J   Colacino Evelina E  

Beilstein journal of organic chemistry 20170104


The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under dry-grinding conditions was also performed. The results showed that the cyclization reaction was influenced by the amount of the PEG grinding agents. In general, cleaner reaction profiles were observed in the presence of PEGs, compared to dry-gri  ...[more]

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