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Antitumor magnetic hyperthermia induced by RGD-functionalized Fe3O4 nanoparticles, in an experimental model of colorectal liver metastases.


ABSTRACT: This work reports important advances in the study of magnetic nanoparticles (MNPs) related to their application in different research fields such as magnetic hyperthermia. Nanotherapy based on targeted nanoparticles could become an attractive alternative to conventional oncologic treatments as it allows a local heating in tumoral surroundings without damage to healthy tissue. RGD-peptide-conjugated MNPs have been designed to specifically target ?V?3 receptor-expressing cancer cells, being bound the RGD peptides by "click chemistry" due to its selectivity and applicability. The thermal decomposition of iron metallo-organic precursors yield homogeneous Fe3O4 nanoparticles that have been properly functionalized with RGD peptides, and the preparation of magnetic fluids has been achieved. The nanoparticles were characterized by transmission electron microscopy (TEM), vibrating sample magnetometry (VSM), electron magnetic resonance (EMR) spectroscopy and magnetic hyperthermia. The nanoparticles present superparamagnetic behavior with very high magnetization values, which yield hyperthermia values above 500 W/g for magnetic fluids. These fluids have been administrated to rats, but instead of injecting MNP fluid directly into liver tumors, intravascular administration of MNPs in animals with induced colorectal tumors has been performed. Afterwards the animals were exposed to an alternating magnetic field in order to achieve hyperthermia. The evolution of an in vivo model has been described, resulting in a significant reduction in tumor viability.

SUBMITTER: Arriortua OK 

PROVIDER: S-EPMC5238624 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Antitumor magnetic hyperthermia induced by RGD-functionalized Fe<sub>3</sub>O<sub>4</sub> nanoparticles, in an experimental model of colorectal liver metastases.

Arriortua Oihane K OK   Garaio Eneko E   Herrero de la Parte Borja B   Insausti Maite M   Lezama Luis L   Plazaola Fernando F   García Jose Angel JA   Aizpurua Jesús M JM   Sagartzazu Maialen M   Irazola Mireia M   Etxebarria Nestor N   García-Alonso Ignacio I   Saiz-López Alberto A   Echevarria-Uraga José Javier JJ  

Beilstein journal of nanotechnology 20161028


This work reports important advances in the study of magnetic nanoparticles (MNPs) related to their application in different research fields such as magnetic hyperthermia. Nanotherapy based on targeted nanoparticles could become an attractive alternative to conventional oncologic treatments as it allows a local heating in tumoral surroundings without damage to healthy tissue. RGD-peptide-conjugated MNPs have been designed to specifically target α<sub>V</sub>β<sub>3</sub> receptor-expressing canc  ...[more]

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