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Magnetic hyperthermia with ε-Fe₂O₃ nanoparticles.

ABSTRACT: Biocompatibility restrictions have limited the use of magnetic nanoparticles for magnetic hyperthermia therapy to iron oxides, namely magnetite (Fe₃O₄) and maghemite (γ-Fe₂O₃). However, there is yet another magnetic iron oxide phase that has not been considered so far, in spite of its unique magnetic properties: ε-Fe₂O₃. Indeed, whereas Fe₃O₄ and γ-Fe₂O₃ have a relatively low magnetic coercivity, ε-Fe₂O₃ exhibits a giant coercivity. In this report, the heating power of ε-Fe₂O₃ nanoparticles in comparison with γ-Fe₂O₃ nanoparticles of similar size (∼20 nm) was measured in a wide range of field frequencies and amplitudes, in uncoated and polymer-coated samples. It was found that ε-Fe₂O₃ nanoparticles primarily heat in the low-frequency regime (20-100 kHz) in media whose viscosity is similar to that of cell cytoplasm. In contrast, γ-Fe₂O₃ nanoparticles heat more effectively in the high frequency range (400-900 kHz). Cell culture experiments exhibited no toxicity in a wide range of nanoparticle concentrations and a high internalization rate. In conclusion, the performance of ε-Fe₂O₃ nanoparticles is slightly inferior to that of γ-Fe₂O₃ nanoparticles in human magnetic hyperthermia applications. However, these ε-Fe₂O₃ nanoparticles open the way for switchable magnetic heating owing to their distinct response to frequency.

SUBMITTER: Gu Y

PROVIDER: S-EPMC9055867 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Magnetic hyperthermia with ε-Fe2O3 nanoparticles.

Gu Yuanyu Y Yoshikiyo Marie M Namai Asuka A Bonvin Debora D Martinez Abelardo A Piñol Rafael R Téllez Pedro P Silva Nuno J O NJO Ahrentorp Fredrik F Johansson Christer C Marco-Brualla Joaquín J Moreno-Loshuertos Raquel R Fernández-Silva Patricio P Cui Yuwen Y Ohkoshi Shin-Ichi SI Millán Angel A

RSC advances 20200804 48

Biocompatibility restrictions have limited the use of magnetic nanoparticles for magnetic hyperthermia therapy to iron oxides, namely magnetite (Fe3O4) and maghemite (γ-Fe2O3). However, there is yet another magnetic iron oxide phase that has not been considered so far, in spite of its unique magnetic properties: ε-Fe2O3. Indeed, whereas Fe3O4 and γ-Fe2O3 have a relatively low magnetic co ...[more]

PMID: 35520081

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Project description:Green synthesis of nanoparticles (NPs) is eco-friendly, biocompatible, cost-effective, and highly stable. In the present study, Citrus sinensis peel extract was utilized to the fabrication of superparamagnetic iron oxide nanoparticles (SPIONs). The fabricated SPIONs were first characterized using UV-Visible spectroscopy, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Transmission electron microscopy (TEM), and vibrating sample magnetometer (VSM). The UV-Vis spectra analysis displayed a peak at 259 nm due to the surface plasmon resonance. The FTIR spectrum showed bands at 3306 cm-1, and 1616 cm-1 revealed the protein's involvement in the development and capping of NPs. TEM analysis indicated that green synthesized SPIONs were spherical in shape with particle size of 20-24 nm. Magnetization measurements indicate that the synthesized SPIONs exhibited superparamagnetic behavior at room temperature. The antimicrobial activity, minimum inhibitory concentration (MIC), antioxidant potential, anti-inflammatory effect, and catalytic degradation of methylene blue by SPIONs were investigated in this study. Results demonstrated that SPIONs had variable antimicrobial effect against different pathogenic multi-drug resistant bacteria. At the highest concentration (400 μg/mL), SPIONs showed inhibition zones (14.7-37.3 mm) against all the target isolates. Furthermore, the MIC of synthesized SPIONs against Staphylococcus aureus, Streptococcus mutans, Bacillus subtilis, Escherichia coli, Klebsiella pneumonia, and Candida albicans were 3, 6.5, 6.5, 12.5, 50, 25 μg/mL, respectively. SPIONs exhibited strong antioxidant, anti-inflammatory, and catalytic dye degradation activities. Interestingly, Fe3O4 SPIONs shows optimum magnetic hyperthermia (MHT) techniques under an alternating magnetic field (AMF) measured in specific absorption rate (SAR) of 164, 230, and 286 W/g at concentrations 1, 5, and 10 mg/mL, respectively. Additionally, these newly fabricated SPIONs virtually achieve significant execution under the AMF in fluid MHT and are suitable for biomedical applications.

Project description:Among iron oxide phases, magnetite (Fe3O4) is often the preferred one for nanotechnological and biomedical applications because of its high saturation magnetization and low toxicity. Although there are several synthetic routes that attempt to reach magnetite nanoparticles (NPs), they are usually referred as "IONPs" (iron oxide NPs) due to the great difficulty in obtaining the monophasic and stoichiometric Fe3O4 phase. Added to this problem is the common increase of size/shape polydispersity when larger NPs (D > 20 nm) are synthesized. An unequivocal correlation between a nanomaterial and its properties can only be achieved by the production of highly homogeneous systems, which, in turn, is only possible by the continuous improvement of synthesis methods. There is no doubt that solving the compositional heterogeneity of IONPs while keeping them monodisperse remains a challenge for synthetic chemistry. Herein, we present a methodical optimization of the iron oleate decomposition method to obtain Fe3O4 single nanocrystals without any trace of secondary phases and with no need of postsynthetic treatment. The average dimension of the NPs, ranging from 20 to 40 nm, has been tailored by adjusting the total volume and the boiling point of the reaction mixture. Mössbauer spectroscopy and DC magnetometry have revealed that the NPs present a perfectly stoichiometric Fe3O4 phase. The high saturation magnetization (93 (2) A·m2/kg at RT) and the extremely sharp Verwey transition (at around 120 K) shown by these NPs have no precedent. Moreover, the synthesis method has been refined to obtain NPs with octahedral morphology and suitable magnetic anisotropy, which significantly improves the magnetic hyperthemia performance. The heating power of properly PEGylated nano-octahedrons has been investigated by AC magnetometry, confirming that the NPs present negligible dipolar interactions, which leads to an outstanding magnetothermal efficiency that does not change when the NPs are dispersed in environments with high viscosity and ionic strength. Additionally, the heat production of the NPs within physiological media has been directly measured by calorimetry under clinically safe conditions, reasserting the excellent adequacy of the system for hyperthermia therapies. To the best of our knowledge, this is the first time that such bulklike magnetite NPs (with minimal size/shape polydispersity, minor agglomeration, and exceptional heating power) are chemically synthesized.

Dataset Information

Magnetic hyperthermia with ε-Fe₂O₃ nanoparticles.

Publications

Magnetic hyperthermia with ε-Fe<sub>2</sub>O<sub>3</sub> nanoparticles.

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