MiR?223?3p regulates cell growth and apoptosis via FBXW7 suggesting an oncogenic role in human testicular germ cell tumors.
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ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC5238776 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
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miR‑223‑3p regulates cell growth and apoptosis via FBXW7 suggesting an oncogenic role in human testicular germ cell tumors.
Liu Jikai J Shi Hao H Li Xidan X Chen Gang G Larsson Catharina C Lui Weng-Onn WO
International journal of oncology 20161215 2
miR‑223‑3p is deregulated in several tumor types and plays an important role in tumorigenesis and progression. However, its role in the pathogenesis of testicular germ cell tumor (TGCT) remains uncharacterized. We previously demonstrated that miR‑223‑3p expression was increased in TGCTs compared with normal testes (NT), suggesting that miR‑223‑3p may have an oncogenic role in TGCT. Using published dataset and The Cancer Genome Atlas database, we validated higher miR‑223‑3p expression in TGCTs th ...[more]
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