Dataset Information

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.

ABSTRACT: Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.

SUBMITTER: Stucki D

PROVIDER: S-EPMC5238942 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.

Stucki David D Brites Daniela D Jeljeli Leïla L Coscolla Mireia M Liu Qingyun Q Trauner Andrej A Fenner Lukas L Rutaihwa Liliana L Borrell Sonia S Luo Tao T Gao Qian Q Kato-Maeda Midori M Ballif Marie M Egger Matthias M Macedo Rita R Mardassi Helmi H Moreno Milagros M Tudo Vilanova Griselda G Fyfe Janet J Globan Maria M Thomas Jackson J Jamieson Frances F Guthrie Jennifer L JL Asante-Poku Adwoa A Yeboah-Manu Dorothy D Wampande Eddie E Ssengooba Willy W Joloba Moses M Henry Boom W W Basu Indira I Bower James J Saraiva Margarida M Vaconcellos Sidra E G SEG Suffys Philip P Koch Anastasia A Wilkinson Robert R Gail-Bekker Linda L Malla Bijaya B Ley Serej D SD Beck Hans-Peter HP de Jong Bouke C BC Toit Kadri K Sanchez-Padilla Elisabeth E Bonnet Maryline M Gil-Brusola Ana A Frank Matthias M Penlap Beng Veronique N VN Eisenach Kathleen K Alani Issam I Wangui Ndung'u Perpetual P Revathi Gunturu G Gehre Florian F Akter Suriya S Ntoumi Francine F Stewart-Isherwood Lynsey L Ntinginya Nyanda E NE Rachow Andrea A Hoelscher Michael M Cirillo Daniela Maria DM Skenders Girts G Hoffner Sven S Bakonyte Daiva D Stakenas Petras P Diel Roland R Crudu Valeriu V Moldovan Olga O Al-Hajoj Sahal S Otero Larissa L Barletta Francesca F Jane Carter E E Diero Lameck L Supply Philip P Comas Iñaki I Niemann Stefan S Gagneux Sebastien S

Nature genetics 20161031 12

Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses sh ...[more]

PMID: 27798628

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Project description:BackgroundWe describe the identification of, and risk factors for, the single most prevalent Mycobacterium tuberculosis strain in the West Midlands region of the UK.Methodology/principal findingsProspective 15-locus MIRU-VNTR genotyping of all M. tuberculosis isolates in the West Midlands between 2004 and 2008 was undertaken. Two retrospective epidemiological investigations were also undertaken using univariable and multivariable logistic regression analysis. The first study of all TB patients in the West Midlands between 2004 and 2008 identified a single prevalent strain in each of the study years (total 155/3,056 (5%) isolates). This prevalent MIRU-VNTR profile (32333 2432515314 434443183) remained clustered after typing with an additional 9-loci MIRU-VNTR and spoligotyping. The majority of these patients (122/155, 79%) resided in three major cities located within a 40 km radius. From the apparent geographical restriction, we have named this the "Mercian" strain. A multivariate analysis of all TB patients in the West Midlands identified that infection with a Mercian strain was significantly associated with being UK-born (OR = ?9.03, 95%CI = 4.56-17.87, p<0.01), Black Caribbean (OR = 5.68, 95%CI = 2.96-10.91, p < 0.01) resident in Wolverhampton (OR = 9.29, 95%CI = 5.69-15.19, p < 0.01) and negatively associated with age >65 years old (OR = 0.25, 95% CI = 0.09-0.67, p < 0.01). A second more detailed investigation analyzed a cohort of 82 patients resident in Wolverhampton between 2003 and 2006. A significant association with being born in the UK remained after a multivariate analysis (OR = 9.68, 95% CI = 2.00-46.78, p < 0.01) and excess alcohol intake and cannabis use (OR = 6.26, 95%CI = 1.45-27.02, p =? .01) were observed as social risk factors for infection.Conclusions/significanceThe continued consistent presence of the Mercian strain suggests ongoing community transmission. Whilst significant associations have been found, there may be other common risk factors yet to be identified. Future investigations should focus on targeting the relevant risk groups and elucidating the biological factors that mediate continued transmission of this strain.

Dataset Information

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.

Publications

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.

Similar Datasets

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