Ontology highlight
ABSTRACT:
SUBMITTER: Phelan J
PROVIDER: S-EPMC5760664 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Phelan Jody J de Sessions Paola Florez PF Tientcheu Leopold L Perdigao Joao J Machado Diana D Hasan Rumina R Hasan Zahra Z Bergval Indra L IL Anthony Richard R McNerney Ruth R Antonio Martin M Portugal Isabel I Viveiros Miguel M Campino Susana S Hibberd Martin L ML Clark Taane G TG
Scientific reports 20180109 1
DNA methylation is an epigenetic modification of the genome involved in regulating crucial cellular processes, including transcription and chromosome stability. Advances in PacBio sequencing technologies can be used to robustly reveal methylation sites. The methylome of the Mycobacterium tuberculosis complex is poorly understood but may be involved in virulence, hypoxic survival and the emergence of drug resistance. In the most extensive study to date, we characterise the methylome across the 4 ...[more]