Ontology highlight
ABSTRACT:
SUBMITTER: Du J
PROVIDER: S-EPMC5239546 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Du Juan J Wu Jinfeng J Fu Xiuqiong X Tse Anfernee Kai-Wing AK Li Ting T Su Tao T Yu Zhi-Ling ZL
Oncotarget 20160801 32
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising antitumor agent. However, many melanoma cells show weak responses to TRAIL. Here, we investigated whether Icariside II (IS), an active component of Herba Epimedii, could potentiate antitumor effects of TRAIL in melanoma cells. Melanoma cells were treated with IS and/or TRAIL and cell death, apoptosis and signal transduction were analyzed. We showed that IS promoted TRAIL-induced cell death and apoptosis in A375 melano ...[more]