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Sclerosing Orbital Inflammation Caused by Leishmania braziliensis.

ABSTRACT: Orbital biopsy of nonspecific orbital inflammation, commonly referred to as "orbital pseudotumor," typically shows a combination of polyclonal lymphocytes, plasmocytes, leukocytes, macrophages, and variable degrees of collagen deposition. Herein, we report a patient with a positive history of mucocutaneous leishmaniasis who presented with an orbital mass with a histological profile of idiopathic orbital inflammation. Immunohistochemical and molecular analysis of the orbital specimens demonstrated that the orbital inflammation was associated with the presence of antigens of Leishmania braziliensis and DNA from the parasite.

SUBMITTER: Cruz AA

PROVIDER: S-EPMC5239692 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Sclerosing Orbital Inflammation Caused by Leishmania braziliensis.

Cruz Antonio Augusto V AA Alves-Ferreira Eliza V C EV Milbratz-Moré Gherusa G Chahud Fernando F Ruy Patricia C PC Duarte Maria Irma Seixas MI Cruz Angela Kaysel AK

The American journal of tropical medicine and hygiene 20161031 1

Orbital biopsy of nonspecific orbital inflammation, commonly referred to as "orbital pseudotumor," typically shows a combination of polyclonal lymphocytes, plasmocytes, leukocytes, macrophages, and variable degrees of collagen deposition. Herein, we report a patient with a positive history of mucocutaneous leishmaniasis who presented with an orbital mass with a histological profile of idiopathic orbital inflammation. Immunohistochemical and molecular analysis of the orbital specimens demonstrate ...[more]

PMID: 27799649

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