Ontology highlight
ABSTRACT:
SUBMITTER: Wells A
PROVIDER: S-EPMC5240004 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Wells Adam A Romberger Debra J DJ Thiele Geoffrey M GM Wyatt Todd A TA Staab Elizabeth E Heires Art J AJ Klassen Lynell W LW Duryee Michael J MJ Mikuls Ted R TR Dusad Anand A West William W WW Wang Dong D Poole Jill A JA
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20161122 1
Airway and skeletal diseases are prominent among agriculture workers. Repetitive inhalant exposures to agriculture organic dust extract (ODE) induces bone deterioration in mice; yet the mechanisms responsible for connecting the lung-bone inflammatory axis remain unclear. We hypothesized that the interleukin (IL)-6 effector response regulates bone deterioration following inhalant ODE exposures. Using an established intranasal inhalation exposure model, wild-type (WT) and IL-6 knockout (KO) mice w ...[more]