Ontology highlight
ABSTRACT:
SUBMITTER: Reindl J
PROVIDER: S-EPMC5240115 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Reindl Judith J Girst Stefanie S Walsh Dietrich W M DW Greubel Christoph C Schwarz Benjamin B Siebenwirth Christian C Drexler Guido A GA Friedl Anna A AA Dollinger Günther G
Scientific reports 20170117
The spatial distribution of DSB repair factors γH2AX, 53BP1 and Rad51 in ionizing radiation induced foci (IRIF) in HeLa cells using super resolution STED nanoscopy after low and high linear energy transfer (LET) irradiation was investigated. 53BP1 and γH2AX form IRIF with same mean size of (540 ± 40) nm after high LET irradiation while the size after low LET irradiation is significantly smaller. The IRIF of both repair factors show nanostructures with partial anti-correlation. These structures a ...[more]