Ontology highlight
ABSTRACT:
SUBMITTER: Chertok B
PROVIDER: S-EPMC5240524 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Chertok Beata B Langer Robert R Anderson Daniel G DG
ACS nano 20160729 8
We developed a method to spatially control gene expression following nonviral delivery of DNA. This method includes surface-modifying DNA nanocarriers with heparin to inhibit passive gene transfer in both the target and the off-target tissues and using ultrasound-targeted microbubble destruction (UTMD) to selectively activate heparin-inhibited gene transfer at the target site. We observed that the engraftment of heparin onto the surface of cationic liposomes reduced off-target gene expression in ...[more]