Ontology highlight
ABSTRACT:
SUBMITTER: Zhao J
PROVIDER: S-EPMC5240722 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Zhao Jingyao J Chen Xufeng X Song Guangrong G Zhang Jiali J Liu Haifeng H Liu Xiaolong X
Proceedings of the National Academy of Sciences of the United States of America 20161212 2
Hematopoietic stem cells (HSCs) are able to both self-renew and differentiate. However, how individual HSC makes the decision between self-renewal and differentiation remains largely unknown. Here we report that ablation of the key epigenetic regulator Uhrf1 in the hematopoietic system depletes the HSC pool, leading to hematopoietic failure and lethality. Uhrf1-deficient HSCs display normal survival and proliferation, yet undergo erythroid-biased differentiation at the expense of self-renewal ca ...[more]