Ontology highlight
ABSTRACT:
SUBMITTER: Elia L
PROVIDER: S-EPMC5983314 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Elia Leonardo L Kunderfranco Paolo P Carullo Pierluigi P Vacchiano Marco M Farina Floriana Maria FM Hall Ignacio Fernando IF Mantero Stefano S Panico Cristina C Papait Roberto R Condorelli Gianluigi G Quintavalle Manuela M
The Journal of clinical investigation 20180507 6
Adult vascular smooth muscle cells (VSMCs) dedifferentiate in response to extracellular cues such as vascular damage and inflammation. Dedifferentiated VSMCs are proliferative, migratory, less contractile, and can contribute to vascular repair as well as to cardiovascular pathologies such as intimal hyperplasia/restenosis in coronary artery and arterial aneurysm. We here demonstrate the role of ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) as an epigenetic master regulator of V ...[more]