Ontology highlight
ABSTRACT:
SUBMITTER: Zhmurov A
PROVIDER: S-EPMC5240993 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Zhmurov Artem A Protopopova Anna D AD Litvinov Rustem I RI Zhukov Pavel P Mukhitov Alexander R AR Weisel John W JW Barsegov Valeri V
Structure (London, England : 1993) 20160929 11
Fibrin is a filamentous network made in blood to stem bleeding; it forms when fibrinogen is converted into fibrin monomers that self-associate into oligomers and then to polymers. To gather structural insights into fibrin formation and properties, we combined high-resolution atomic force microscopy of fibrin(ogen) oligomers and molecular modeling of crystal structures of fibrin(ogen) and its fragments. We provided a structural basis for the intermolecular flexibility of single-stranded fibrin(og ...[more]