Ontology highlight
ABSTRACT:
SUBMITTER: Timilshina M
PROVIDER: S-EPMC5241145 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Timilshina Maheshwor M Kang Youra Y Dahal Ishmit I You Zhiwei Z Nam Tae-Gyu TG Kim Keuk-Jun KJ Jeong Byeong-Seon BS Chang Jae-Hoon JH
PloS one 20170117 1
CD4+ T cells are essential in inflammation and autoimmune diseases. Interferon-γ (IFN-γ) secreting T helper (Th1) and IL-17 secreting T helper (Th17) cells are critical for several autoimmune diseases. To assess the inhibitory effect of a given compound on autoimmune disease, we screened many compounds with an in vitro Th differentiation assay. BJ-3105, a 6-alkoxypyridin-3-ol analog, inhibited IFN-γ and IL-17 production from polyclonal CD4+ T cells and ovalbumin (OVA)-specific CD4+ T cells which ...[more]