Ontology highlight
ABSTRACT:
SUBMITTER: McMichael EL
PROVIDER: S-EPMC5241232 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
McMichael Elizabeth L EL Jaime-Ramirez Alena Cristina AC Guenterberg Kristan D KD Luedke Eric E Atwal Lakhvir S LS Campbell Amanda R AR Hu Zhiwei Z Tatum Armika S AS Kondadasula Sri Vidya SV Mo Xiaokui X Tridandapani Susheela S Bloomston Mark M Ellison E Christopher EC Williams Terence M TM Bekaii-Saab Tanios T Carson William E WE
Clinical cancer research : an official journal of the American Association for Cancer Research 20160719 2
<h4>Purpose</h4>Alternative strategies to EGFR blockage by mAbs is necessary to improve the efficacy of therapy in patients with locally advanced or metastatic pancreatic cancer. One such strategy includes the use of NK cells to clear cetuximab-coated tumor cells, as need for novel therapeutic approaches to enhance the efficacy of cetuximab is evident. We show that IL-21 enhances NK cell-mediated effector functions against cetuximab-coated pancreatic tumor cells irrespective of KRAS mutation sta ...[more]