Ontology highlight
ABSTRACT:
SUBMITTER: Chua MJ
PROVIDER: S-EPMC5241585 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Chua Ming Jang MJ Arnold Megan S J MS Xu Weijun W Lancelot Julien J Lamotte Suzanne S Späth Gerald F GF Prina Eric E Pierce Raymond J RJ Fairlie David P DP Skinner-Adams Tina S TS Andrews Katherine T KT
International journal for parasitology. Drugs and drug resistance 20161223 1
Malaria, schistosomiasis and leishmaniases are among the most prevalent tropical parasitic diseases and each requires new innovative treatments. Targeting essential parasite pathways, such as those that regulate gene expression and cell cycle progression, is a key strategy for discovering new drug leads. In this study, four clinically approved anti-cancer drugs (Vorinostat, Belinostat, Panobinostat and Romidepsin) that target histone/lysine deacetylase enzymes were examined for in vitro activity ...[more]