Syndecan-4 as a biomarker to predict clinical outcome for glioblastoma multiforme treated with WT1 peptide vaccine.
Ontology highlight
ABSTRACT: Aim
In cancer immunotherapy, biomarkers are important for identification of responsive patients. This study was aimed to find biomarkers that predict clinical outcome of WT1 peptide vaccination.Materials & methods
Candidate genes that were expressed differentially between long- and short-term survivors were identified by cDNA microarray analysis of peripheral blood mononuclear cells that were extracted from 30 glioblastoma patients (discovery set) prior to vaccination and validated by quantitative RT-PCR using discovery set and different 23 patients (validation set).Results
SDC-4 mRNA expression levels distinguished between the long- and short-term survivors: 1-year survival rates were 64.0 and 18.5% in SDC4-low and -high patients, respectively.Conclusion
SDC-4 is a novel predictive biomarker for the efficacy of WT1 peptide vaccine.
SUBMITTER: Takashima S
PROVIDER: S-EPMC5241910 | biostudies-literature |
REPOSITORIES: biostudies-literature
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