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WT1 Trio Peptide-vaccine for Rare Cancers

ABSTRACT: Interventions: A patient is vaccinated with Montanide ISA51-adjuvanted WT1 Trio cancer vaccine consisting of two WT1 CTL peptides (WT1-126 and WT1-235) and one WT1 HTL peptide (WT1-332) (2mg each) seven times at the interval of two weeks. Primary outcome(s): Induction of WT1-specific immune responses assessed by WT1-related tests such as WT1-DTH skin reaction and serum levels of WT1 peptide IgG autoantibody at 1M, 2M, and 3M of WT1 Trio vaccine. Study Design: Single arm Non-randomized

DISEASE(S): Thymic Cancer Thymoma Soft Tissue Sarcoma Malignant Glioma Salivary Gland Cancer Head And Neck Mucoepidermoid Carcinoma Olfactory Neuroblastoma Head And Neck Mucosal Malignant Melanoma Ophthalmic Malignant Melanoma Cancer Of The External Auditory Canal Testicular Cancer Cancer Of Penis Adrenal Cancer Malignant Mesothelioma Cancer Of The Small Intestine Merkel Cell Carcinoma Cutaneous Lymphoma (rare Cancers Listed Above)

PROVIDER: 2638832 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Phase I Clinical trial of personalized peptide vaccine in combination with humanized anti-IL6 receptor monoclonal antibody for refractory colorectal cancer patients

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