Ontology highlight
ABSTRACT:
SUBMITTER: Liang S
PROVIDER: S-EPMC5241969 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Liang Siqi S Tippens Nathaniel D ND Zhou Yaoda Y Mort Matthew M Stenson Peter D PD Cooper David N DN Yu Haiyuan H
Genome biology 20170118 1
The mechanistic details of most disease-causing mutations remain poorly explored within the context of regulatory networks. We present a high-resolution three-dimensional integrated regulatory network (iRegNet3D) in the form of a web tool, where we resolve the interfaces of all known transcription factor (TF)-TF, TF-DNA and chromatin-chromatin interactions for the analysis of both coding and non-coding disease-associated mutations to obtain mechanistic insights into their functional impact. Usin ...[more]