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Magnetic Multivalent Trehalose Glycopolymer Nanoparticles for the Detection of Mycobacteria.

ABSTRACT: A multivalent trehalose-grafted poly(lactic acid) is synthesized and encapsulated with iron oxide magnetic nanoparticles. The magnetic micelles interact with Mycobacterium smegmatis to form orange clusters. Very little particle interaction is found on Staphylococcus epidermidis 35984 or Escherichia coli ORN 208. The presented new approach to the detection of mycobacteria does not require molecular biology reagents or sophisticated instruments.

SUBMITTER: Chen X

PROVIDER: S-EPMC5242184 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Magnetic Multivalent Trehalose Glycopolymer Nanoparticles for the Detection of Mycobacteria.

Chen Xuan X Wu Bin B Jayawardana Kalana W KW Hao Nanjing N Jayawardena H Surangi N HS Langer Robert R Jaklenec Ana A Yan Mingdi M

Advanced healthcare materials 20160610 16

A multivalent trehalose-grafted poly(lactic acid) is synthesized and encapsulated with iron oxide magnetic nanoparticles. The magnetic micelles interact with Mycobacterium smegmatis to form orange clusters. Very little particle interaction is found on Staphylococcus epidermidis 35984 or Escherichia coli ORN 208. The presented new approach to the detection of mycobacteria does not require molecular biology reagents or sophisticated instruments. ...[more]

PMID: 27283385

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