Ontology highlight
ABSTRACT:
SUBMITTER: Johnson SL
PROVIDER: S-EPMC5242392 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
The Journal of neuroscience : the official journal of the Society for Neuroscience 20170101 2
Mutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin 30 (Cx30) have been linked to syndromic and nonsyndromic hearing loss in mice and humans. The release of ATP from connexin hemichannels in cochlear nonsensory cells has been proposed to be the main trigger for action potential activity in immature sensory inner hair cells (IHCs), which is crucial for the refinement of the developing auditory circuitry. Using connexin knock-out mice, we show that IHCs fire s ...[more]