Ontology highlight
ABSTRACT:
SUBMITTER: Bonacci T
PROVIDER: S-EPMC5242482 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Bonacci Thomas T Audebert Stéphane S Camoin Luc L Baudelet Emilie E Iovanna Juan-Lucio JL Soubeyran Philippe P
PloS one 20170118 1
NUB1 (Nedd8 ultimate buster 1) is an adaptor protein which negatively regulates the ubiquitin-like protein Nedd8 as well as neddylated proteins levels through proteasomal degradation. However, molecular mechanisms underlying this function are not completely understood. Here, we report that the oncogenic E3 ubiquitin ligase Mdm2 is a new NUB1 interacting protein which induces its ubiquitination. Interestingly, we found that Mdm2-mediated ubiquitination of NUB1 is not a proteolytic signal. Instead ...[more]