Ontology highlight
ABSTRACT:
SUBMITTER: Qin LX
PROVIDER: S-EPMC524279 | biostudies-literature | 2004
REPOSITORIES: biostudies-literature
Qin Li-Xuan LX Kerr Kathleen F KF
Nucleic acids research 20041012 18
There are many options in handling microarray data that can affect study conclusions, sometimes drastically. Working with a two-color platform, this study uses ten spike-in microarray experiments to evaluate the relative effectiveness of some of these options for the experimental goal of detecting differential expression. We consider two data transformations, background subtraction and intensity normalization, as well as six different statistics for detecting differentially expressed genes. Find ...[more]