Ontology highlight
ABSTRACT:
SUBMITTER: Wen R
PROVIDER: S-EPMC524341 | biostudies-literature | 2004 Oct
REPOSITORIES: biostudies-literature
Wen Renren R Chen Yuhong Y Schuman James J Fu Guoping G Yang Shoua S Zhang Weiguo W Newman Debra K DK Wang Demin D
The EMBO journal 20040916 20
Phospholipase Cgamma1 (PLCgamma1) has been reported to be expressed predominantly in T cells and to play an important role in T-cell receptor signaling. Here we show that PLCgamma1 is expressed throughout B-cell development, with high expression in B-cell progenitors, and is involved in pre-B-cell receptor (pre-BCR) signaling. Reduced expression of PLCgamma1, in the absence of PLCgamma2 (PLCgamma1+/-PLCgamma2-/-), impedes early B-cell development at the pro-B- to pre-B-cell transition and impair ...[more]