Ontology highlight
ABSTRACT:
SUBMITTER: Li F
PROVIDER: S-EPMC2626684 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Li Fubin F Eckhardt Laurel A LA
The Journal of experimental medicine 20081229 1
The intronic enhancer (E mu) of the immunoglobulin heavy chain (IgH) locus is critical for V region gene assembly. To determine E mu's subsequent functions, we created an Igh allele with assembled V(H) gene but with E mu removed. In mice homozygous for this E mu-deficient allele, B cell development was normal and indistinguishable from that of mice with the same V(H) knockin and E mu intact. In mice heterozygous for the E mu-deficient allele, however, allelic exclusion was severely compromised. ...[more]