Ontology highlight
ABSTRACT:
SUBMITTER: Ng SB
PROVIDER: S-EPMC5244357 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Ng Sarah B SB Chua Clarinda C Ng Matthew M Gan Anna A Poon Polly Sy PS Teo Melissa M Fu Cherylin C Leow Wei Qiang WQ Lim Kiat Hon KH Chung Alexander A Koo Si-Lin SL Choo Su Pin SP Ho Danliang D Rozen Steve S Tan Patrick P Wong Mark M Burkholder William F WF Tan Iain Beehuat IB
Scientific reports 20170119
Circulating tumour DNA (ctDNA) has the potential to be a specific biomarker for the monitoring of tumours in patients with colorectal cancer (CRC). Here, our aim was to develop a personalised surveillance strategy to monitor the clinical course of CRC after surgery. We developed patient-specific ctDNA assays based on multiplexed detection of somatic mutations identified from patient primary tumours, and applied them to detect ctDNA in 44 CRC patients, analysing a total of 260 plasma samples. We ...[more]