Ontology highlight
ABSTRACT:
SUBMITTER: Ea CK
PROVIDER: S-EPMC524439 | biostudies-literature | 2004 Oct
REPOSITORIES: biostudies-literature
Ea Chee-Kwee CK Sun Lijun L Inoue Jun-Ichiro J Chen Zhijian J ZJ
Proceedings of the National Academy of Sciences of the United States of America 20041018 43
TRAF6 (tumor necrosis factor receptor-associated factor 6) is a RING (really interesting new gene) domain ubiquitin (Ub) ligase that mediates the activation of protein kinases, such as transforming growth factor beta-activated kinase (TAK1) and IkappaB kinase (IKK), by catalyzing the formation of a unique polyubiquitin chain linked through Lys-63 of Ub. Here, we present evidence that TIFA (TRAF-interacting protein with a forkhead-associated domain, also known as T2BP) activates IKK by promoting ...[more]