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The burden of amyloid light chain amyloidosis on health-related quality of life.


ABSTRACT: Light chain (AL) amyloidosis is a rare disease characterized by misfolded amyloid protein deposits in tissues and vital organs, and little is known about the burden of AL amyloidosis on health-related quality of life. This study aimed to quantify the burden of AL amyloidosis in terms of health-related quality of life in a diverse, community-based sample of AL amyloidosis patients.The SF-36v2® Health Survey (SF-36v2), a widely used generic measure of health-related quality of life (using physical and mental summary scales and subscales assessing eight aspects of functioning and well-being), was administered as an online survey of AL amyloidosis patients with AL amyloidosis (ClinicalTrials.gov, NCT02574676 ; n?=?341). Compared with adjusted general population sample norms, health-related quality of life of AL amyloidosis patients was significantly worse across all SF-36v2 scales and summary measures based on analysis of variance (p?

SUBMITTER: Bayliss M 

PROVIDER: S-EPMC5244523 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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The burden of amyloid light chain amyloidosis on health-related quality of life.

Bayliss Martha M   McCausland Kristen L KL   Guthrie Spencer D SD   White Michelle K MK  

Orphanet journal of rare diseases 20170119 1


<h4>Background</h4>Light chain (AL) amyloidosis is a rare disease characterized by misfolded amyloid protein deposits in tissues and vital organs, and little is known about the burden of AL amyloidosis on health-related quality of life. This study aimed to quantify the burden of AL amyloidosis in terms of health-related quality of life in a diverse, community-based sample of AL amyloidosis patients.<h4>Results</h4>The SF-36v2® Health Survey (SF-36v2), a widely used generic measure of health-rela  ...[more]

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